A Low - affinity Antagonist Reveals Saturation and Desensitization in Mature 1 Synapses in the Auditory Brainstem
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چکیده
A Low-affinity Antagonist Reveals Saturation and Desensitization in Mature 1 Synapses in the Auditory Brainstem 2 3 Soham Chanda and Matthew A. Xu-Friedman* 4 Department of Biological Science, School of Arts and Sciences, State University of New 5 York at Buffalo, 109 Cooke Hall, Buffalo, NY 14260, USA 6 7 8 9 10 11 12 Running Title: Desensitization at mature endbulbs 13 14 15 Number of words in abstract: 233 16 Number of Figures: 9 17 Number of supplementary figures: 5 18 Number of Tables: 1 19 Number of pages: 33 20 21
منابع مشابه
A low-affinity antagonist reveals saturation and desensitization in mature synapses in the auditory brain stem.
Postsynaptic receptor desensitization has been observed to contribute to depression in immature synapses. However, it is not clear whether desensitization persists and causes depression in mature synapses. We investigate this issue at the endbulb of Held, the synapse made by auditory nerve (AN) fibers onto bushy cells (BCs) of the anteroventral cochlear nucleus, where depression could influence...
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Glutamatergic synapses of layer 6 corticothalamic (CT) neurons form a major excitatory input onto thalamic relay cells, allowing neocortex to continuously control sensory information processing in thalamic circuits. CT synapses display both short- and long-term forms of use-dependent synaptic enhancement, mediated at least in part by increases in the probability of transmitter release. At some ...
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